Guitarists
- Ibrahim Ag Alhabib – guitarist for the band Tinariwen
- Barthelemy Attisso – lead guitarist for Orchestre Baobab from Senegal
- Afel Bocoum – Malian guitarist who was a student of Ali Farka Touré
- Omara "Bombino" Moctar – Tuareg guitarist and singer from Agadez, Niger, known worldwide
- Henri Bowane – important figure in the development of Congo rumba, early teacher of Franco
- Oliver De Coque – leader of Ogene Sound Super of Africa
- Victor Démé – singer and guitarist from Burkina Faso
- Fatoumata Diawara – Malian guitarist and singer
- Diblo Dibala – Congolese soukous musician known as "Machine Gun" for his fast guitar playing
- Mamadou Diop (also known as Modou Diop) – Senegalese rhythm guitarist now living in the United States
- Sona Jobarteh – Griot kora player, singer, and guitarist from Gambia
- Nico Kasanda (a.k.a. "Dr. Nico") – early creator of soukous music
- Omar Khorshid – skilled Egyptian guitarist who played with singers such as Farid Al Atrash, Umm Kulthum, Mohamed Abdel Wahab, and Abdel Halim Hafez
- Habib Koité – vocalist and guitarist from Mali
- Ismaël Lô – Senegalese musician and actor
- Alick Macheso – bass guitarist for his own band Orchestra Mberikwazvo from Zimbabwe
- François Luambo Makiadi (a.k.a. "Franco") – Congolese musician who started the important group OK Jazz
- Michelino Mavatiku Visi (a.k.a. "Michelino") – soukous musician, composer, guitarist, and singer
- Nico Mbarga – lead guitarist and composer of the song "Sweet Mother"
- Louis Mhlanga – Zimbabwean guitarist and music producer
- Oliver Mtukudzi – guitarist from Zimbabwe, leader of the Black Spirits
- Mono Mukundu – Zimbabwean music producer, composer, and multi-instrumentalist
- Jean-Bosco Mwenda – pioneer of African fingerstyle guitar in the 1950s from Congo
- Ray Phiri – lead guitarist from Mpumalanga, South Africa, who played on Paul Simon's album Graceland
- Jonah Sithole – Zimbabwean guitarist who played with Thomas Mapfumo
- Ebo Taylor – Ghanaian guitarist who plays Highlife and Afrobeat music, friend of Fela Kuti
- Boubacar Traoré – Malian guitarist who plays folk and blues music
- Djelimady Tounkara – lead guitarist for the Super Rail Band from Bamako, Mali
- Ali Farka Touré – singer and guitarist from Mali
- Vieux Farka Touré – son of Ali Farka Touré, a young rising star from Mali
- Rokia Traoré – Malian songwriter and guitarist
- Sir Victor Uwaifo – guitarist from the Bini/Edo-speaking people, based in Benin City, Edo State, Nigeria
- Dr Sir Warrior – vocalist and guitarist for the Oriental Brothers International Band