Entertainment and art

• G. B. W. Lewis (George Benjamin William Lewis, 1818–1906), circus performer and theater manager in Australia
• George E. Lewis (born 1952), American composer and free jazz trombonist
• George J. Lewis (1903–1995), Mexican-born American actor
• George Robert Lewis (1782–1871), English painter of landscapes and portraits
• George Lewis (clarinetist) (1900–1968), New Orleans jazz clarrettist
• George Lewis, Jr. aka Twin Shadow (born 1983), Dominican-American musician and actor

Politics

• George Lowys or Lewis (active around 1536), mayor of Winchelsea
• George Lewis (Member of Parliament for Cardiff), served as a Member of Parliament for Cardiff in 1586
• George Cornewall Lewis (1806–1863), British government official
• George Lewis (politician) (1820–1887), American official who served as mayor of Roxbury, Massachusetts

Sports

• George Lewis (athlete) (1917–2011), track and field athlete from Trinidad and Tobago
• George Lewis (footballer, born 1875) (1875–?), English footballer
• George Lewis (footballer, born 1913) (1913–1981), footballer who played for Watford and Southampton
• George Lewis (footballer, born 2000), footballer born in Rwanda and later played in Norway
• George Lewis (rugby league), rugby league footballer who played in the 1920s, 1930s, and 1940s
• George Lewis (rugby) (1897–1988), Welsh footballer who played rugby union and rugby league
• Duffy Lewis (George Edward Lewis, 1888–1979), Major League Baseball player

Other

• George Lewis (British Army officer) (1735–1791), British colonel
• George Lewis (Royal Marines officer) (1774–1854), served in the Napoleonic Wars and War of 1812
• George Lewis (entomologist) (1839–1926), English scientist who studied insects
• George W. Lewis (1882–1948), director of aeronautical research at NACA
• George Lewis (journalist) (born 1943), American television reporter
• Sir George Lewis, 1st Baronet (1833–1911), UK solicitor, baronet
• Slave George (1794–1811), murder victim, also known as George Lewis
• George Lewis (priest) (died 1730), Archdeacon of Meath
• George F. Lewis (1828–1890), American journalist and newspaper proprietor
• George Edward Lewis (paleontologist) (1908–1997), American scientist who studied ancient life